Heart Failure – NEET PG Case-Based MCQ Quiz

Early signs • NYHA classification • Treatment algorithm • Drugs & decisions

Heart Failure
NEET PG
Case-Based MCQs
HFrEF & HFpEF
Q1
Core Rx

A 62-year-old man with prior MI complains of exertional breathlessness. Echo shows LVEF 32%. He is on ACE inhibitor and beta-blocker. HR = 78/min, BNP is elevated. Which additional drug will further reduce HF mortality?

Correct: A. Dapagliflozin (SGLT2 inhibitor reduces mortality in HFrEF).
Q2
NYHA Class

A 55-year-old woman has shortness of breath on climbing a single flight of stairs. She is comfortable at rest but has marked limitation for daily tasks. What is her NYHA functional class?

Correct: B. NYHA III – marked limitation, comfortable only at rest.
Q3
ACEI Intolerance

A patient with HFrEF on ACE inhibitor develops a persistent dry cough. Echo shows EF 30%. What is the most appropriate replacement?

Correct: C. Switch to ARB (losartan/valsartan).
Q4
Acute HF

A 70-year-old man presents with acute severe dyspnea, frothy sputum and BP 170/100 mmHg. On exam he has bilateral crepitations. What is the first-line acute therapy?

Correct: B. Standard acute pulmonary edema management.
Q5
SGLT2i

A 50-year-old diabetic with EF 38% is on ARNI, beta-blocker and spironolactone. Which additional drug reduces HF mortality and works even in non-diabetics?

Correct: B. SGLT2 inhibitor.
Q6
Spironolactone

A patient on spironolactone for HF presents with muscle weakness and ECG showing peaked T waves. Which abnormal lab value is most likely?

Correct: B. Hyperkalemia due to aldosterone antagonism.
Q7
Ivabradine

A 65-year-old man with HFrEF (EF 28%) has HR 82/min despite maximum tolerated beta-blocker. Which drug specifically acts on SA node “funny current” (If) to lower heart rate?

Correct: B. Ivabradine.
Q8
ARNI

A patient with HFrEF is to be started on sacubitril/valsartan (ARNI). He is currently on an ACE inhibitor. What is the correct approach?

Correct: C. 36-hour washout to avoid angioedema.
Q9
CXR

A 58-year-old man with orthopnea and PND has suspected HF. On chest X-ray, what is an early sign of pulmonary venous congestion?

Correct: B. Cephalization is an early radiologic sign.
Q10
HFpEF

A 52-year-old woman with long-standing hypertension presents with exertional dyspnea. Echo shows preserved EF with concentric LVH. Which is the best treatment strategy?

Correct: C. Symptom relief + risk factor control + SGLT2i.
Q11
Loops

A HF patient is started on furosemide. Which electrolyte disturbance is most typical?

Correct: B. Loop diuretics cause K⁺ loss.
Q12
HFpEF Dx

A dyspneic patient has raised BNP but echocardiography reveals normal EF with diastolic dysfunction. What is the likely diagnosis?

Correct: C. HF with preserved EF.
Q13
ACEI MOA

A HF patient given high-dose ACE inhibitor develops symptomatic hypotension. What is the key mechanism?

Correct: B. ACEI ↓ Ang II → vasodilation → hypotension.
Q14
Beta-blocker

A HF patient on carvedilol comes with BP 86/60 mmHg and dizziness. What is the most appropriate change in therapy?

Correct: A. First adjust beta-blocker causing hypotension.
Q15
NYHA IV

A 67-year-old man reports severe dyspnea at rest and is unable to perform any physical activity without discomfort. NYHA class?

Correct: C. NYHA IV – symptoms at rest.
Q16
Digoxin Toxicity

A patient on digoxin develops nausea, yellow vision and ventricular arrhythmias. Which electrolyte abnormality predisposes to this toxicity?

Correct: B. Hypokalemia increases digoxin binding & toxicity.
Q17
Right HF

A HF patient presents with raised JVP, tender hepatomegaly and bilateral pitting edema, but minimal pulmonary crepitations. What does this most likely indicate?

Correct: B. Systemic congestion → right HF.
Q18
NYHA vs EF

A 45-year-old with EF 25% can perform ordinary activities with only mild limitation. He has dyspnea on more than ordinary exertion but not at rest. Current NYHA class?

Correct: D. Symptoms with ordinary exertion → NYHA II.
Q19
SGLT2 AEs

A HF patient on SGLT2 inhibitor develops mild recurrent genital mycotic infections. He otherwise feels much better and wants to continue. Best approach?

Correct: B. Manage side effect; continue if mild.
Q20
Pulm Edema

A HF patient suddenly develops pink frothy sputum and severe breathlessness. What is the underlying pathophysiology?

Correct: B. Acute LV failure → pulmonary edema.
Q21
Volume Status

A known HF patient gains 3 kg over 3 days and complains of worsening ankle swelling. What is the most appropriate immediate adjustment?

Correct: B. Sudden weight gain indicates fluid retention.
Q22
Preload & Afterload

Which drug in HF simultaneously reduces both preload and afterload by venous and arterial vasodilation, especially useful in acute pulmonary edema?

Correct: B. Nitrates act primarily venodilator but also reduce afterload.
Q23
Gynecomastia

A man on spironolactone for HF complains of painful breast enlargement. What is the mechanism behind this adverse effect?

Correct: B. Spironolactone has anti-androgen activity.
Q24
Contraindication

A patient with HFrEF is started on verapamil for rate control. What is the likely effect on his HF?

Correct: C. Non-DHP CCBs worsen systolic HF.
Q25
HTN & HFpEF

A 75-year-old diabetic with HFpEF has BP 150/92 mmHg. Which class is preferred as baseline BP control with prognostic benefit?

Correct: B. RAAS blockers help HTN and HFpEF risk factors.
Q26
Drug Combo

A patient with HFrEF is mistakenly given sacubitril/valsartan together with an ACE inhibitor. Which complication is particularly feared with this combination?

Correct: C. ACEI + ARNI greatly ↑ angioedema risk.
Q27
Device Rx

A HF patient with EF 20%, repeated hospitalizations and QRS duration 160 ms has LBBB pattern. Which device therapy improves survival by resynchronizing ventricles?

Correct: B. CRT for wide QRS with systolic HF.
Q28
Hyponatremia

A chronic HF patient is found to have hyponatremia (Na⁺ 124 mEq/L). What is the main mechanism in HF-related dilutional hyponatremia?

Correct: B. Non-osmotic ADH release in HF.
Q29
Shock

A 60-year-old HF patient presents with cold clammy extremities, confusion, and systolic BP 75 mmHg. Which diagnosis best fits this hemodynamic state?

Correct: C. Classic low-output cardiogenic shock.
Q30
Symptoms vs Survival

A 50-year-old man with EF 30% is stable on guideline-directed therapy but has reduced exercise tolerance. Which drug improves symptoms and reduces hospitalization but does not reduce mortality?

Correct: C. Digoxin improves symptoms, not survival.
Score: 0 / 30 | Correct: 0 | Wrong: 0
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